Medusa is the Queen of the Inhumans and the primary interpreter for her husband Black Bolt, the King of the Inhumans. Medusa is best known for her long, thick head of red hair, which she can psychokinetically wield like countless extra appendages.

Medusa's most notable feature is her unusually long and luxurious red hair (six feet in length when fully relaxed), the strands of which are no thicker than the average strand of human hair and just as soft when she wills it to be. However, each strand possesses greater tensile strength and durability than steel wire of the same thickness, and Medusa has the psychokinetic ability to wield all of them like countless extra appendages. With concentration, she can move her hair in almost any manner imaginable.